The IPT policy has achieved limited success in low and middle-income countries.  With limited empirical research exploring the barriers to suboptimal IPT uptake, it is important to understand this knowledge gap.  Also, limited programmatic strategies exist to address this problem.  Therefore, studying the barriers to and facilitators for IPT uptake would serve public health for prevention of TB among adult PLHIV in India and similar HIV-TB burdened settings.  Dissemination of this evidence will help to identify strategies and devise targeted interventions to enhance IPT uptake.  As newer TB preventive regimens are being planned, this study could serve as a reference for their successful implementation in near future. 

As outlined in the WHO End TB Strategy, it is critical to address the HIV/TB co-infection to reduce the morbidity and mortality associated it.  With far reaching consequences of COVID-19 pandemic on health priorities, preventing TB in PLHIV forms the backbone of the national, regional and international response to combat the triple threat.  To scale up the IPT uptake among PLHIV, it is essential to understand the challenges and the motivational factors in TB prevention care cascade.  This research project can help translate the commitments made at the United Nations high-level meeting of the General Assembly on TB research into action by generating new scientific evidence which could guide policies and operational strategies to strengthen the care cascade for optimizing the IPT uptake.